通知通告

新闻类别:通知通告
2019-03-27

【报告通知】Light field 3D confocal endoscopy and its application in the diagnosis of early cancer of upper gastrointestinal tract


报告题目: Light field 3D confocal endoscopy and its application in the diagnosis of early cancer of upper gastrointestinal tract
时         间:2019年3月29日10:30-12:00
地         点:武汉光电国家研究中心A302
报   告  人:王璞 教授    北京航空航天大学
邀   请  人:王平 教授

时         间:2019年3月29日10:30-12:00
地         点:武汉光电国家研究中心A302
报   告  人:王璞 教授    北京航空航天大学
邀   请  人:王平 教授

【摘要】
The survival rate of upper gastrointestinal cancer is closely related to the tumor stage. Therefore, it is crucial to diagnose upper gastrointestinal cancer early. Unfortunately, current endoscopy methods suffer from either poor resolution or penetration depth, which thus limits the accuracy of early diagnosis. Herein, in order to address such unmet clinical need, we have developed a light-field three-dimensional confocal laser endomicroscopy, which leverages the characteristic of light chromatic dispersion. Specifically, a super continuum light source (400-1100 nm) and lenses with high dispersion were utilized to provide a wide range of spectrum, which can be focused on different depth of the tissue (0 ~ 300 μm) simultaneously. The reflected confocal signal was then collected through a single mode fiber. A multi-channel acquisition chip was finally used to generate a 3D image at a time with a speed of five 3D images per second. The lateral resolution was ~2 μm, and the axial resolution was ~4 μm. Given the cellular resolution, large imaging depth, and fast 3D imaging capabilities, 3D confocal laser endomicroscopy has been demonstrated to be able to image fresh upper gastrointestinal tissues from patients and provide sufficient tissue information at submucosal layer for accurate diagnosis.


【个人简介】

国家青年千人计划特聘教授。2014年于美国普渡大学获得博士学位。长期从事无标记分子光谱学成像和光声成像的器械研发和应用,已发表SCI论文20篇,其中包括以第一作者身份发表的Nature Photonics, Science Advances, Light:Science&Applications等顶级论文。以项目申请人的身份获得美国NIH、NSF和美国印第安纳州政府约100万美金的研发基金,并通过与医院团队的深度合作,在精准光学诊疗器械的研发与转化方面积累了丰富的经验。


【医工交叉领域科研方向】
CARS显微镜小型化
瞬态吸收显微镜的设备开发
介入式血管内诊疗一体化的设备开发
多模态内窥镜成像系统

【近5年代表性科研项目】
血管内光声成像系统
饱和吸收瞬态显微镜系统
术中光声成像在肿瘤切缘检测的应用
术中软组织定位导航技术

【近5年发表论文】
1. Lu Lan, Yan Xia, Rui Li, Kaiming Liu, Jieying Mai, Jennifer Anne Medley, Samilia Obeng-Gyasi, Linda K Han, and Pu Wang*, Ji-Xin Cheng*, “A Fiber Optoacoustic Guide with Augmented Reality for Precision Breast Conserving Surgery”, Light: Science & Applications, (2018)
2. Haonan Lin#, Chien-Sheng Liao#, Pu Wang#, and Nan Kong, Ji-Xin Cheng, “Spectroscopic Stimulated Raman Scattering Imaging of Highly Dynamic Specimens through Matrix Completion”, Light: Science & Applications, (2018)
3. Chien-Sheng Liao#, Pu Wang#, Ping Wang, Junjie Li, Hyeon Jeong Lee, Gregory Eakins, Ji-Xin Cheng, “Spectrometer-free vibrational imaging by retrieving stimulated Raman signal from highly scattered photons”, Science Advances, 1 (9), e1500738.(2015)
4. Pu Wang#, Mikhail N. Slipchenko#, James Mitchell, Chen Yang, Eric O. Potma, Xianfan Xu, and Ji-Xin Cheng, “Far-field Imaging of Non-fluorescent Species with Sub-diffraction Resolution”, Nature Photonics, 7(9) 449-453 (2013)
5. Pu Wang, Justin R. Rajian and Ji-Xin Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration”, Journal of Physical Chemistry Letters, 4, 2177-2185 (2013)