通知通告

新闻类别:通知通告
2016-05-06

【报告通知】Altered Cholesterol Metabolism: New Avenue to Diagnosis and Treatment of Human Prostate Cancer

 

报告题目:Altered Cholesterol Metabolism: New Avenue to Diagnosis and Treatment of Human Prostate Cancer
时间:5月10日上午10:00
地点:武汉光电国家实验室G300
报告人:岳蜀华,北京航空航天大学教授
邀请人:王平教授

报告人简介:

   岳蜀华,2003至2007年就读于清华大学生物医学工程专业,2007年7月获学士学位。2007至2013年赴美国普渡大学(Purdue University - West Lafayette)攻读博士学位,生物医学工程专业。2013年12月获博士学位。2014年入选北京航空航天大学“卓越百人计划”,获聘副教授。一直从事国际前沿的无标记光谱显微成像系统的研发,为单细胞的定量分析提供新的方法,用于探索细胞生物学中的重要科学问题。已发表学术论文18篇,其中有1篇第一作者论文以亮点文章的形式发表于顶级科学类杂志Cell子刊——Cell Metabolism,影响因子17.565。该论文一经发表,立刻被Nature以“High cholesterol in prostate tumours”为标题做突出介绍。自2014年发表以来,这篇文章已被SCI引用40次,被评为高被引论文。在美科研工作期间,获得多项学术荣誉,其中包括2014年国际光学工程学会转化研究最佳论文奖、普渡大学癌症中心Miles博士生荣誉奖学金、Ronald Dollens博士生荣誉奖学金等。

报告摘要(Abstract):

Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases. Biochemical study showed that such cholesteryl ester accumulation was a consequence of loss of tumor suppressor PTEN and subsequent activation of PI3K/AKT pathway in prostate cancer cells. Furthermore, we found that such accumulation arose from significantly enhanced uptake of exogenous lipoproteins and required cholesterol esterification. Depletion of cholesteryl ester storage significantly reduced cancer proliferation, impaired cancer invasion capability, and suppressed tumor growth in mouse xenograft models with negligible toxicity. These findings open opportunities for diagnosing and treating prostate cancer by targeting the altered cholesterol metabolism.
Yue, Shuhua, et al. Cell Metabolism (2014)