时 间：2019年6月17日，下午16:00-17:30
地 点：武汉光电国家研究中心A202
报告人：Hui Lu （吕辉）, Department of Pharmacology and Physiology, The George Washington University, Washington, DC
邀请人：曾绍群教授
Biography：
Neural computations depend on the propagation of signals through finely-tuned and precisely-wired circuit components in the brain. This conclusion has been reached by directly relating the dynamic function of neural circuits to sensory experience and behavior. It is a compelling hypothesis that genetic mutations which perturb cognition and behavior, such as those associated with autism, mediate their effects by disrupting these finely-tuned and precisely-wired circuits and thereby altering neural information processing. From this point of view, measuring how neural circuit function is altered in autism models provides a window into important principles of optimal neural circuit function. Equally important, a better understanding of the biological basis of autism will likely lead to better therapies for autism and other disorders of neural circuit function (“circuitopathies”).
Research Interest：
The long-term goal of Lu lab is to use state-of-the-art in vivo Ca2+ imaging technique, mouse genetics and optogenetics to characterize malfunction of the neural circuit in mouse models of autism spectrum disorders (ASD) and to explore the possibility of intervention and rescue.
